Rituximab may form a complex with iGmκ mixed cryoglobulin and induce severe systemic reactions in patients with hepatitis C virusâinduced vasculitis
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چکیده
منابع مشابه
the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Long-term remission with rituximab in a patient with severe hepatitis C virus-induced mixed cryoglobulinemia.
Mixed cryoglobulinemia (MC) is a small-vessel systemic vasculitis characterized by the presence of cryoglobulins, immunoglobulin complexes that precipitate at low temperatures ( < 37 ºC) inducing the inflammatory process. The most frequent etiology is hepatitis C infection (HCV) (1). Rituximab (RTX), an anti-CD20 monoclonal antibody, has recently emerged as the treatment of choice for severe MC...
متن کاملCryoglobulinemia in patients with hepatitis C
Introduction: Cryoglobulinemia is a kind of immunoglobuline that form in various conditions. These imunoglobulines, precipitate in cold environment and restore to soluble state upon rewarming. Nowadays, strong association between cryoglobulines and hepatitis C has been proposed. Methods: This is a descriptive-analytic study in which we included all documented cases of hepatitis C infection wh...
متن کاملSafety and efficacy of rituximab in patients with hepatitis C virus-related mixed cryoglobulinemia and severe liver disease.
The effectiveness of rituximab in hepatitis C virus (HCV)-related mixed cryoglobulinemia (MC) has been shown. However, the risk of an increase in viral replication limits its use in cirrhosis, a condition frequently observed in patients with MC. In this prospective study, 19 HCV-positive patients with MC and advanced liver disease, who were excluded from antiviral therapy, were treated with rit...
متن کاملSafety and efficacy of rituximab treatment for vasculitis in hepatitis B virus-associated type II cryoglobulinemia: a case report
INTRODUCTION Systemic B-cell depletion and clinical remission of the systemic effects of cryoglobulins have already been achieved using rituximab in hepatitis C virus-positive immunocompetent patients. Conversely, to the best of our knowledge there are no reports in the literature regarding the use of rituximab in hepatitis B virus-associated cryoglobulinemia. CASE PRESENTATION We report here...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2009
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.25000